Psalm 103:13, As a father pities [shows compassion] to his children, so the Lord shows compassion to those who fear him. 14 For He knows our frame; He remembers that we are dust.

"Frame” means a person’s God-given structure, design, gifts, and purpose, imagination, intellectual framework. Design is critical to the success and proper functioning of anything or anyone.
One of the definitions of abuse is "abnormal use.” 

Isa 29:16, Surely your turning of things upside down shall be esteemed as the potter's clay: for shall the work say of him that made it, He made me not? or shall the thing framed say of him that framed it, He had no understanding?